Relative Incidence of Office Visits and… Vaccine Study

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“Abstract: We performed a retrospective analysis spanning ten years of pediatric practice focused
on patients with variable vaccination born into a practice, presenting a unique opportunity to
study the effects of variable vaccination on outcomes. The average total incidence of billed office
visits per outcome related to the outcomes were compared across groups (Relative Incidence of
Office Visit (RIOV)). RIOV is shown to be more powerful than odds ratio of diagnoses. Full cohort,
cumulative incidence analyses, matched for days of care, and matched for family history analyses were
conducted across quantiles of vaccine uptake. Increased office visits related to many diagnoses were
robust to days-of-care-matched analyses, family history, gender block, age block, and false discovery
risk. Many outcomes had high RIOV odds ratios after matching for days-of-care (e.g., anemia
(6.334), asthma (3.496), allergic rhinitis (6.479), and sinusitis (3.529), all significant under the Z-test).
Developmental disorders were determined to be difficult to study due to extremely low prevalence
in the practice, potentially attributable to high rates of vaccine cessation upon adverse events and
family history of autoimmunity. Remarkably, zero of the 561 unvaccinated patients in the study
had attention deficit hyperactivity disorder (ADHD) compared to 0.063% of the (partially and fully)
vaccinated. The implications of these results for the net public health effects of whole-population
vaccination and with respect for informed consent on human health are compelling. Our results
give agency to calls for research conducted by individuals who are independent of any funding
sources related to the vaccine industry. While the low rates of developmental disorders prevented
sufficiently powered hypothesis testing, it is notable that the overall rate of autism spectrum disorder
(0.84%) in the cohort is half that of the US national rate (1.69%). The practice-wide rate of ADHD was
roughly half of the national rate. The data indicate that unvaccinated children in the practice are not
unhealthier than the vaccinated and indeed the overall results may indicate that the unvaccinated
pediatric patients in this practice are healthier overall than the vaccinated.”

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